Alzheimer's Research

Dementia is not one specific disease; it is a term used to describe a group of symptoms associated with cognitive or mental decline. Such as, a decline in memory, concentration, or other thinking skills severe enough to reduce a person’s ability to perform usual activities. Alzheimer’s disease accounts for 60 to 80 percent of cases, and is the most common cause of a progressive dementia in older adults, but there are a number of causes of dementia. Keep in mind, having memory problems alone doesn’t mean you have dementia.

Alzheimer’s disease is a progressive disorder that causes brain cells to waste away (degenerate) and die. Alzheimer’s disease is not a normal part of aging. Memory problems are typically one of the first warning signs of cognitive loss. Alzheimer’s disease is the most common cause of dementia — a continuous decline in thinking, behavioral and social skills that disrupts a person’s ability to function independently. The early signs of the disease may be forgetting recent events or conversations. As the disease progresses, a person with Alzheimer’s disease will develop severe memory impairment and lose the ability to carry daily activities.

According to the National Institute on Aging, in addition to memory problems, someone with Alzheimer’s disease may experience one or more of the following signs:

  • Repetitive questions or conversations 
  • Misplacing personal belongings
  • Forgetting events or appointments
  • Getting lost on a familiar route
  • Repetitive questions or conversations 
  • Poor understanding of safety risks
  • Inability to manage finances
  • Poor decision-making ability 
  • Inability to plan complex or sequential activities
  • Inability to recognize faces or common objects or to find objects in direct view
  • Inability to use simple tools, for example, to orient clothing to the body
  •  Difficulty thinking of common words while speaking, hesitations
  • Speech, spelling, and writing errors
  • Out-of-character mood changes, including agitation, apathy, social withdrawal or a lack of interest, motivation, or initiative
  • Loss of empathy
  • Compulsive, obsessive, or socially unacceptable behavior

Current Studies

ASCEND – EIP19-NFD-501: ​A Double-Blind, Placebo-Controlled 16-Week Study of the Cognitive Effects of the Oral P38 Alpha Kinase Inhibitor Neflamapimod in Dementia with Lewy Bodies (DLB)