OTHER Research

Coming in 2021-22 to INWR

Amyotrophic lateral sclerosis (ALS) is also known as Motor Neuron Disease (MND) or Lou Gehrig’s. ALS, is a rare neurological diseases that mainly involve the nerve cells (neurons) responsible for controlling voluntary muscle movement, like walking, talking, breathing and eating. ALS causes deterioration of the motor neurons from the brain, spinal cord and muscles, causing motor symptoms to worsen over time. ALS does not usually affect the senses– taste, smell, touch, hearing, or sight. ALS also dose not typically impair or lessen the ability to think (cognition). 

ALS affects people differently, making it difficult to predict how the quickly the disease will progress. Most people live about 3-5 years after they notice first signs of ALS. About 1 in 10 people live 10 years or longer. Currently, there is no cure for ALS and no effective treatment to halt, or reverse, the progression of the disease.

  • Levodopa: Doctors have been treating PD with Levodopa for the past 50 years. As the brain loses the ability to create and convert dopamine in the brain, symptoms worsen. Lovodopa helps replace the dopamine that is no longer produced because of PD.  Commonly, you will see carbidopa combined with levodopa, to help minimize side effects.

    • Common pill forms include: Sinemet, Rytary, CD/LD

    • Intestinal Infusion: Duodopa

  • Dopamine Agonists: Is often used before the use of Levodopa, to treat motor symptoms of PD; though dopamine agonists can also be used in combination with Levodopa. Dopamin agonists are designed to act like dopamine, stimulating dopamine receptors in the brain.

    • Common pill forms include: Pramapexole, ropinirole Injectables: Apomorphine

    • Patches: Rotigotine

  • Monoamine Oxidanse B (MAOB) Inhibitors: Help to keep dopamine in the brain longer, by blocking enzymes known as MAOB, which break down dopamine in the brain.

    • Common MAOB Inhibitors include: Rasagiline (Azilec) and Selegiline 

  • Deep Brain Stimulation (DBS): Is used to control PD symptoms when oral medications stop working or become significantly less affective. DBS is a surgical prcedure that places electrodes (electrical stimulation to the brain). The electrodes use high frequency stimulation on the parts of the brain that help control PD symptoms. 

ALS Clinical Trial